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Title | Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV. |
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Journal, issue, pages | J. Med. Chem., Vol. 54, Page 510-524, Year 2011 |
Publish date | Jan 27, 2009 (structure data deposition date) |
Authors | Zhang, Z. / Wallace, M.B. / Feng, J. / Stafford, J.A. / Skene, R.J. / Shi, L. / Lee, B. / Aertgeerts, K. / Jennings, A. / Xu, R. ...Zhang, Z. / Wallace, M.B. / Feng, J. / Stafford, J.A. / Skene, R.J. / Shi, L. / Lee, B. / Aertgeerts, K. / Jennings, A. / Xu, R. / Kassel, D.B. / Kaldor, S.W. / Navre, M. / Webb, D.R. / Gwaltney, S.L. |
External links | J. Med. Chem. / PubMed:21186796 |
Methods | X-ray diffraction |
Resolution | 2.25 - 2.69 Å |
Structure data | PDB-3g0b: PDB-3g0c: PDB-3g0d: PDB-3g0g: |
Chemicals | ChemComp-NAG: ChemComp-T22: ChemComp-HOH: ChemComp-RUF: ChemComp-XIH: ChemComp-RUM: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / protease and 8-bladed beta-propeller domain / Aminopeptidase / Cell membrane / Glycoprotein / Hydrolase / Membrane / Protease / Secreted / Serine protease / Signal-anchor / Transmembrane / HYDROLASE-HYDROLASE INHIBITOR complex / DPP4 / pyrimidinone / pyrimidindione |