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Structure paper

TitleUnexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Journal, issue, pagesNucleic Acids Res., Vol. 39, Page 3482-3495, Year 2011
Publish dateOct 6, 2010 (structure data deposition date)
AuthorsPallan, P.S. / Greene, E.M. / Jicman, P.A. / Pandey, R.K. / Manoharan, M. / Rozners, E. / Egli, M.
External linksNucleic Acids Res. / PubMed:21183463
MethodsX-ray diffraction
Resolution1.15 - 1.85 Å
Structure data

PDB-3p4a:
2'Fluoro modified RNA octamer fA2U2
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-3p4b:
Alternatingly modified 2'Fluoro RNA octamer f/rA2U2-P3
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-3p4c:
Alternatingly modified 2'Fluoro RNA octamer f/rA2U2-R32
Method: X-RAY DIFFRACTION / Resolution: 1.15 Å

PDB-3p4d:
Alternatingly modified 2'Fluoro RNA octamer f/rC4G4
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-SR:
STRONTIUM ION

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-BA:
Unknown entry

Source
  • synthetic construct (others)
KeywordsRNA / 2'-FLUORO-RNA / O2'-MODIFICATION / OCTAMER / 2'-fluoro 2'-deoxycytidine / 2'-fluoro 2'-deoxyguanosine / 2'-fluoro 2'-deoxyadenosine / 2'-fluoro 2'-deoxyuridine / siRNA / 2'-FLUORO-RNA O2'-MODIFICATION

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