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TitleInteractions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex
Journal, issue, pagesJ. Med. Chem., Vol. 54, Page 909-912, Year 2011
Publish dateNov 22, 2010 (structure data deposition date)
AuthorsBinda, C. / Aldeco, M. / Mattevi, A. / Edmondson, D.E.
External linksJ. Med. Chem. / PubMed:21175212
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3po7:
Human monoamine oxidase B in complex with zonisamide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-ZON:
1-(1,2-benzoxazol-3-yl)methanesulfonamide / medication*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / flavin-binding amine oxidase / neurotransmitter metabolism / FAD / mitochondrial outer membrane / antiparkinson drug / OXIDOREDUCTASE / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

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