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TitleEngineering a High Affinity Anti-Il-15 Antibody: Crystal Structure Reveals an Alpha-Helix in Vh Cdr3 as Key Component of Paratope.
Journal, issue, pagesJ. Mol. Biol., Vol. 406, Page 160-, Year 2011
Publish dateSep 1, 2010 (structure data deposition date)
AuthorsLowe, D.C. / Gerhardt, S. / Ward, A. / Hargreaves, D. / Anderson, M. / Ferraro, F. / Pauptit, R.A. / Pattison, D.V. / Buchanan, C. / Popovic, B. ...Lowe, D.C. / Gerhardt, S. / Ward, A. / Hargreaves, D. / Anderson, M. / Ferraro, F. / Pauptit, R.A. / Pattison, D.V. / Buchanan, C. / Popovic, B. / Finch, D.K. / Wilkinson, T. / Sleeman, M. / Vaughan, T.J. / Mallinder, P.R.
External linksJ. Mol. Biol. / PubMed:21167836
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-2xqb:
Crystal Structure of anti-IL-15 Antibody in Complex with human IL-15
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / AFFINITY MATURATION

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