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Structure paper

TitleRigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 6685-6696, Year 2011
Publish dateSep 9, 2010 (structure data deposition date)
AuthorsYu, C. / Sonnen, A.F.-P. / George, R. / Dessailly, B.H. / Stagg, L.J. / Evans, E.J. / Orengo, C.A. / Stuart, D.I. / Ladbury, J.E. / Ikemizu, S. ...Yu, C. / Sonnen, A.F.-P. / George, R. / Dessailly, B.H. / Stagg, L.J. / Evans, E.J. / Orengo, C.A. / Stuart, D.I. / Ladbury, J.E. / Ikemizu, S. / Gilbert, R.J.C. / Davis, S.J.
External linksJ. Biol. Chem. / PubMed:21156796
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3osk:
Crystal structure of human CTLA-4 apo homodimer
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Beta sandwich / Homodimer / Immunoglobulin superfamily (beta sandwich) fold / Receptor / Signalling / B7-1(CD80) / B7-2(CD86) / Membrane

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