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-Structure paper
Title | Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition |
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Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 50, Page 542-544, Year 2011 |
Publish date | Aug 25, 2010 (structure data deposition date) |
![]() | Grawert, M.A. / Gallastegui, N. / Stein, M. / Schmidt, B. / Kloetzel, P.M. / Huber, R. / Groll, M. |
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Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | ![]() PDB-3okj: |
Chemicals | ![]() ChemComp-EP9: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / ubiquitin / protease / inhibitor / central antiparallel beta-sheet flanked by helices / turnover of ubiquitinated substrates / nucleus / cytosol / HYDROLASE-HYDROLASE INHIBITOR complex |