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-Structure paper
Title | Design and synthesis of potent macrocyclic renin inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 358-362, Year 2011 |
Publish date | Sep 20, 2010 (structure data deposition date) |
Authors | Sund, C. / Belda, O. / Wiktelius, D. / Sahlberg, C. / Vrang, L. / Sedig, S. / Hamelink, E. / Henderson, I. / Agback, T. / Jansson, K. ...Sund, C. / Belda, O. / Wiktelius, D. / Sahlberg, C. / Vrang, L. / Sedig, S. / Hamelink, E. / Henderson, I. / Agback, T. / Jansson, K. / Borkakoti, N. / Derbyshire, D. / Eneroth, A. / Samuelsson, B. |
External links | Bioorg. Med. Chem. Lett. / PubMed:21112780 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-3own: |
Chemicals | ChemComp-ACT: ChemComp-NA: ChemComp-3OX: ChemComp-3OW: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / RENIN / PROTEASE / ASPARTYL PROTEASE / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |