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Structure paper

TitleThree Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post- Translational Carboxylation of Lys70.
Journal, issue, pagesBiochem. J., Vol. 432, Page 495-, Year 2010
Publish dateApr 27, 2009 (structure data deposition date)
AuthorsVercheval, L. / Bauvois, C. / Di Paolo, A. / Borel, F. / Ferrer, J.L. / Sauvage, E. / Matagne, A. / Frere, J.M. / Charlier, P. / Galleni, M. / Kerff, F.
External linksBiochem. J. / PubMed:21108605
MethodsX-ray diffraction
Resolution1.791 - 2.1 Å
Structure data

PDB-2wgv:
Crystal structure of the OXA-10 V117T mutant at pH 6.5 inhibited by a chloride ion
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2wgw:
Crystal structure of the OXA-10 V117T mutant at pH 8.0
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2wkh:
Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7
Method: X-RAY DIFFRACTION / Resolution: 1.791 Å

PDB-2wki:
Crystal structure of the OXA-10 K70C mutant at pH 7.0
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-CIT:
CITRIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-ZZ7:
(2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • pseudomonas aeruginosa (bacteria)
KeywordsHYDROLASE / ANTIBIOTIC RESISTANCE / PLASMID ENCODED / TRANSPOSABLE / CLASS D BETA-LACTAMASE / CLASS D / BETA-LACTAMASE

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