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Structure paper

TitleAllosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 3323-3331, Year 2011
Publish dateAug 20, 2010 (structure data deposition date)
AuthorsBuhrman, G. / Kumar, V.S. / Cirit, M. / Haugh, J.M. / Mattos, C.
External linksJ. Biol. Chem. / PubMed:21098031
MethodsX-ray diffraction
Resolution1.3 - 1.837 Å
Structure data

PDB-3oiu:
H-RasQ61L with allosteric switch in the "on" state
Method: X-RAY DIFFRACTION / Resolution: 1.32 Å

PDB-3oiv:
H-RasG12V with allosteric switch in the "off" state
Method: X-RAY DIFFRACTION / Resolution: 1.837 Å

PDB-3oiw:
H-RasG12V with allosteric switch in the "on" state
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-CA:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-DTT:
2,3-DIHYDROXY-1,4-DITHIOBUTANE

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / ONCOGENE GTP-BINDING NUCLEOTIDE-BINDING

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