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TitleDanthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 1868-1875, Year 2011
Publish dateJul 2, 2010 (structure data deposition date)
AuthorsZhang, H. / Zhou, R. / Li, L. / Chen, J. / Chen, L. / Li, C. / Ding, H. / Yu, L. / Hu, L. / Jiang, H. / Shen, X.
External linksJ. Biol. Chem. / PubMed:21084305
MethodsX-ray diffraction
Resolution2.6 - 2.9 Å
Structure data

PDB-3nsp:
Crystal structure of tetrameric RXRalpha-LBD
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-3nsq:
Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CHZ:
1,8-dihydroxyanthracene-9,10-dione

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / nuclear receptor retinoic x recepor alpha ligand binding domain / nuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron

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