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TitleStructural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit.
Journal, issue, pagesNucleic Acids Res., Year 2010
Publish dateOct 2, 2010 (structure data deposition date)
AuthorsHusain, N. / Obranic, S. / Koscinski, L. / Seetharaman, J. / Babic, F. / Bujnicki, J.M. / Maravic-Vlahovicek, G. / Sivaraman, J.
External linksNucleic Acids Res. / PubMed:21062819
MethodsX-ray diffraction
Resolution1.68 - 2.7 Å
Structure data

PDB-3p2e:
Structure of an antibiotic related Methyltransferase
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-3p2i:
Structure of an antibiotic related Methyltransferase
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3p2k:
Structure of an antibiotic related Methyltransferase
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-3pb3:
Structure of an Antibiotic Related Methyltransferase
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

ChemComp-SAM:
S-ADENOSYLMETHIONINE

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / Methyltransferase / NpmA / Antibiotic Resistance

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