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Structure paper

TitleThe V alpha 14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.
Journal, issue, pagesJ. Exp. Med., Vol. 207, Page 2383-2393, Year 2010
Publish dateAug 3, 2010 (structure data deposition date)
AuthorsLi, Y. / Girardi, E. / Wang, J. / Yu, E.D. / Painter, G.F. / Kronenberg, M. / Zajonc, D.M.
External linksJ. Exp. Med. / PubMed:20921281
MethodsX-ray diffraction
Resolution2.74 - 2.8 Å
Structure data

PDB-3o8x:
Recognition of Glycolipid Antigen by iNKT Cell TCR
Method: X-RAY DIFFRACTION / Resolution: 2.74 Å

PDB-3o9w:
Recognition of a Glycolipid Antigen by the iNKT Cell TCR
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-GSL:
(2S,3R)-3-HYDROXY-2-(TETRADECANOYLAMINO)OCTADECYL ALPHA-D-GALACTOPYRANOSIDURONIC ACID

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-1O2:
(2S)-3-(alpha-D-galactopyranosyloxy)-2-(hexadecanoyloxy)propyl (9Z)-octadec-9-enoate

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antigen presentation / glycolipid / NKT cells

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