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-Structure paper
Title | An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 132, Page 14942-14950, Year 2010 |
Publish date | Sep 24, 2010 (structure data deposition date) |
Authors | Seth, P.P. / Allerson, C.R. / Berdeja, A. / Siwkowski, A. / Pallan, P.S. / Gaus, H. / Prakash, T.P. / Watt, A.T. / Egli, M. / Swayze, E.E. |
External links | J. Am. Chem. Soc. / PubMed:20886816 |
Methods | X-ray diffraction |
Resolution | 1.36 - 1.59 Å |
Structure data | PDB-3oz3: PDB-3oz4: PDB-3oz5: |
Chemicals | ChemComp-MPD: ChemComp-HOH: ChemComp-SPM: |
Keywords | DNA / A-form DNA / vinyl carbocyclic LNA / antisense oligonucleotides / R-Methyl carbocyclic LNA / R-Me-c-LNA / S-Methyl carbocyclic LNA / S-Me-c-LNA / S-Methyl-carbocyclic LNA |