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Structure paper

TitleStructure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 5988-5993, Year 2010
Publish dateAug 2, 2010 (structure data deposition date)
AuthorsBouloc, N. / Large, J.M. / Kosmopoulou, M. / Sun, C. / Faisal, A. / Matteucci, M. / Reynisson, J. / Brown, N. / Atrash, B. / Blagg, J. ...Bouloc, N. / Large, J.M. / Kosmopoulou, M. / Sun, C. / Faisal, A. / Matteucci, M. / Reynisson, J. / Brown, N. / Atrash, B. / Blagg, J. / McDonald, E. / Linardopoulos, S. / Bayliss, R. / Bavetsias, V.
External linksBioorg. Med. Chem. Lett. / PubMed:20833547
MethodsX-ray diffraction
Resolution2.605 - 2.8 Å
Structure data

PDB-2xne:
Structure of Aurora-A bound to an imidazopyrazine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2xng:
Structure of Aurora-A bound to a selective imidazopyrazine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.605 Å

Chemicals

ChemComp-ASH:
3-chloro-N-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine

ChemComp-HOH:
WATER

ChemComp-A0H:
N-(3-{3-chloro-8-[(4-morpholin-4-ylphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzyl)methanesulfonamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SER-THR PROTEIN KINASE COMPLEX / PROTO-ONCOGENE / KINASE / MITOSIS / CELL CYCLE / MICROTUBULE / CYTOSKELETON / CELL DIVISION

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