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TitlePyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 5984-5987, Year 2010
Publish dateJan 14, 2010 (structure data deposition date)
AuthorsLiu, J.J. / Daniewski, I. / Ding, Q. / Higgins, B. / Ju, G. / Kolinsky, K. / Konzelmann, F. / Lukacs, C. / Pizzolato, G. / Rossman, P. ...Liu, J.J. / Daniewski, I. / Ding, Q. / Higgins, B. / Ju, G. / Kolinsky, K. / Konzelmann, F. / Lukacs, C. / Pizzolato, G. / Rossman, P. / Swain, A. / Thakkar, K. / Wei, C.C. / Miklowski, D. / Yang, H. / Yin, X. / Wovkulich, P.M.
External linksBioorg. Med. Chem. Lett. / PubMed:20832307
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3le6:
The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-2BZ:
5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Cyclin-Dependent Kinase 2 Drug Design / ATP-binding / Cell cycle / Cell division / Kinase / Mitosis / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Transferase-Transferase inhibitor complex

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