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TitleLoop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism.
Journal, issue, pagesJ. Mol. Biol., Vol. 404, Page 45-55, Year 2010
Publish dateJun 14, 2010 (structure data deposition date)
AuthorsPatel, M.P. / Cribb Fabersunne, C.S. / Yang, Y.K. / Kaelin, C.B. / Barsh, G.S. / Millhauser, G.L.
External linksJ. Mol. Biol. / PubMed:20831872
MethodsNMR (solution)
Structure data

PDB-2kza:
Solution structure of ASIP(80-132, P103A, P105A, Q115Y, S124Y)
Method: SOLUTION NMR

PDB-2l1j:
1H assignments for ASIP(93-126, P103A, P105A, P111A, Q115Y, S124Y)
Method: SOLUTION NMR

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / agouti signaling protein / agouti related protein / melanocortin receptor 1 / melanocortin receptor 4 / MC1R / MC4R / AgRP / ASIP / proline-switching

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