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Title4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 6096-6099, Year 2010
Publish dateAug 5, 2010 (structure data deposition date)
AuthorsLiu, K.K. / Bagrodia, S. / Bailey, S. / Cheng, H. / Chen, H. / Gao, L. / Greasley, S. / Hoffman, J.E. / Hu, Q. / Johnson, T.O. ...Liu, K.K. / Bagrodia, S. / Bailey, S. / Cheng, H. / Chen, H. / Gao, L. / Greasley, S. / Hoffman, J.E. / Hu, Q. / Johnson, T.O. / Knighton, D. / Liu, Z. / Marx, M.A. / Nambu, M.D. / Ninkovic, S. / Pascual, B. / Rafidi, K. / Rodgers, C.M. / Smith, G.L. / Sun, S. / Wang, H. / Yang, A. / Yuan, J. / Zou, A.
External linksBioorg. Med. Chem. Lett. / PubMed:20817449
MethodsX-ray diffraction
Resolution2.75 Å
Structure data

PDB-3oaw:
4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-OAW:
2-amino-4-methyl-8-(1-methylethyl)-6-(1H-pyrazol-4-yl)pteridin-7(8H)-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Phosphoinositide kinase / transferase-transferase / inhibition / inhibitor complex. / TRANSFERASE-TRANSFERASE INHIBITOR complex

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