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-Structure paper
タイトル | Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 53, Page 6653-6680, Year 2010 |
掲載日 | 2009年11月19日 (構造データの登録日) |
![]() | Becker, D.P. / Barta, T.E. / Bedell, L.J. / Boehm, T.L. / Bond, B.R. / Carroll, J. / Carron, C.P. / Decrescenzo, G.A. / Easton, A.M. / Freskos, J.N. ...Becker, D.P. / Barta, T.E. / Bedell, L.J. / Boehm, T.L. / Bond, B.R. / Carroll, J. / Carron, C.P. / Decrescenzo, G.A. / Easton, A.M. / Freskos, J.N. / Funckes-Shippy, C.L. / Heron, M. / Hockerman, S. / Howard, C.P. / Kiefer, J.R. / Li, M.H. / Mathis, K.J. / McDonald, J.J. / Mehta, P.P. / Munie, G.E. / Sunyer, T. / Swearingen, C.A. / Villamil, C.I. / Welsch, D. / Williams, J.M. / Yu, Y. / Yao, J. |
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手法 | X線回折 |
解像度 | 1.9 Å |
構造データ | ![]() PDB-3kry: |
化合物 | ![]() ChemComp-ZN: ![]() ChemComp-CA: ![]() ChemComp-3KR: ![]() ChemComp-HOH: |
由来 |
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![]() | HYDROLASE / collagenase / collagenase-3 / MMP-13 / Collagen degradation / Disease mutation / Disulfide bond / Extracellular matrix / Glycoprotein / Metal-binding / Metalloprotease / Protease / Secreted |