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Title | Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 6653-6680, Year 2010 |
Publish date | Nov 19, 2009 (structure data deposition date) |
Authors | Becker, D.P. / Barta, T.E. / Bedell, L.J. / Boehm, T.L. / Bond, B.R. / Carroll, J. / Carron, C.P. / Decrescenzo, G.A. / Easton, A.M. / Freskos, J.N. ...Becker, D.P. / Barta, T.E. / Bedell, L.J. / Boehm, T.L. / Bond, B.R. / Carroll, J. / Carron, C.P. / Decrescenzo, G.A. / Easton, A.M. / Freskos, J.N. / Funckes-Shippy, C.L. / Heron, M. / Hockerman, S. / Howard, C.P. / Kiefer, J.R. / Li, M.H. / Mathis, K.J. / McDonald, J.J. / Mehta, P.P. / Munie, G.E. / Sunyer, T. / Swearingen, C.A. / Villamil, C.I. / Welsch, D. / Williams, J.M. / Yu, Y. / Yao, J. |
External links | J. Med. Chem. / PubMed:20726512 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3kry: |
Chemicals | ChemComp-ZN: ChemComp-CA: ChemComp-3KR: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / collagenase / collagenase-3 / MMP-13 / Collagen degradation / Disease mutation / Disulfide bond / Extracellular matrix / Glycoprotein / Metal-binding / Metalloprotease / Protease / Secreted |