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TitleBotulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Journal, issue, pagesBiochem. J., Vol. 431, Page 207-216, Year 2010
Publish dateAug 9, 2010 (structure data deposition date)
AuthorsStrotmeier, J. / Lee, K. / Volker, A.K. / Mahrhold, S. / Zong, Y. / Zeiser, J. / Zhou, J. / Pich, A. / Bigalke, H. / Binz, T. ...Strotmeier, J. / Lee, K. / Volker, A.K. / Mahrhold, S. / Zong, Y. / Zeiser, J. / Zhou, J. / Pich, A. / Bigalke, H. / Binz, T. / Rummel, A. / Jin, R.
External linksBiochem. J. / PubMed:20704566
MethodsX-ray diffraction
Resolution1.72 - 2 Å
Structure data

PDB-3obr:
Crystal structure of Botulinum neurotoxin serotype D binding domain
Method: X-RAY DIFFRACTION / Resolution: 1.72 Å

PDB-3obt:
Crystal structure of Botulinum neurotoxin serotype D ligand binding domain in complex with N-Acetylneuraminic acid
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SLB:
N-acetyl-beta-neuraminic acid

Source
  • clostridium botulinum (bacteria)
KeywordsHYDROLASE / ligand binding / gangliosides / sNAREs / neurotoxin / gangalioside

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