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TitleDiscovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 5170-5174, Year 2010
Publish dateJun 30, 2010 (structure data deposition date)
AuthorsBelanger, D.B. / Curran, P.J. / Hruza, A. / Voigt, J. / Meng, Z. / Mandal, A.K. / Siddiqui, M.A. / Basso, A.D. / Gray, K.
External linksBioorg. Med. Chem. Lett. / PubMed:20674350
MethodsX-ray diffraction
Resolution3.05 Å
Structure data

PDB-3nrm:
Imidazo[1,2-a]pyrazine-based Aurora Kinase Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

Chemicals

ChemComp-NRM:
N-(3-methylisothiazol-5-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / KINASE / CELL CYCLE / INHIBITOR

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