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TitleInhibition of Hsp90 with Resorcylic Acid Macrolactones. Synthesis and Binding Studies.
Journal, issue, pagesChemistry, Vol. 16, Page 10366-, Year 2010
Publish dateApr 29, 2010 (structure data deposition date)
AuthorsDay, J.E.H. / Sharp, S.Y. / Rowlands, M.G. / Aherne, W. / Lewis, W. / Roe, S.M. / Prodromou, C. / Pearl, L.H. / Workman, P. / Moody, C.J.
External linksChemistry / PubMed:20661961
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2xd6:
Hsp90 complexed with a resorcylic acid macrolactone.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-XD6:
(5Z)-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-3,4,7,8,9,10,11,12-OCTAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-6-CARBALDEHYDE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsCHAPERONE / INHIBITOR / ATPASE

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