| タイトル | Predicting resistance mutations using protein design algorithms. |
|---|
| ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 107, Page 13707-13712, Year 2010 |
|---|
| 掲載日 | 2008年10月25日 (構造データの登録日) |
|---|
著者 | Frey, K.M. / Georgiev, I. / Donald, B.R. / Anderson, A.C. |
|---|
リンク | Proc. Natl. Acad. Sci. USA / PubMed:20643959 |
|---|
| 手法 | X線回折 |
|---|
| 解像度 | 2.08 - 3.15 Å |
|---|
| 構造データ | PDB-3f0q: Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine 手法: X-RAY DIFFRACTION / 解像度: 2.08 Å PDB-3lg4: Staphylococcus aureus V31Y, F92I mutant dihydrofolate reductase complexed with NADPH and 5-[(3S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 手法: X-RAY DIFFRACTION / 解像度: 3.15 Å |
|---|
| 化合物 | ChemComp-NDP: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
ChemComp-52V: 5-[(3S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
|
|---|
| 由来 | staphylococcus aureus rf122 (黄色ブドウ球菌) staphylococcus aureus (黄色ブドウ球菌)
|
|---|
キーワード | OXIDOREDUCTASE / NADP / One-carbon metabolism |
|---|