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TitleCyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 4614-4619, Year 2010
Publish dateApr 1, 2010 (structure data deposition date)
AuthorsYang, H. / Hendricks, R.T. / Arora, N. / Nitzan, D. / Yee, C. / Lucas, M.C. / Yang, Y. / Fung, A. / Rajyaguru, S. / Harris, S.F. ...Yang, H. / Hendricks, R.T. / Arora, N. / Nitzan, D. / Yee, C. / Lucas, M.C. / Yang, Y. / Fung, A. / Rajyaguru, S. / Harris, S.F. / Leveque, V.J. / Hang, J.Q. / Pogam, S.L. / Reuter, D. / Tavares, G.A.
External linksBioorg. Med. Chem. Lett. / PubMed:20584604
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3mf5:
Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HJZ:
3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • hepatitis c virus
KeywordsTRANSFERASE / HCV / HEPATITIS / NS5B / TRANSFERASE RNA-DEPENDENT RNA POLYMERASE

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