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TitleAn allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.
Journal, issue, pagesNat. Biotechnol., Vol. 28, Page 733-737, Year 2010
Publish dateApr 15, 2010 (structure data deposition date)
AuthorsOrlicky, S. / Tang, X. / Neduva, V. / Elowe, N. / Brown, E.D. / Sicheri, F. / Tyers, M.
External linksNat. Biotechnol. / PubMed:20581844
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-3mks:
Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-C1C:
1,1'-binaphthalene-2,2'-dicarboxylic acid

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsLIGASE/CELL CYCLE / ubiquitin ligase / protein binding / small molecule complex / LIGASE-CELL CYCLE complex

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