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-Structure paper
Title | The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38alpha MAP kinase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 3936-3940, Year 2010 |
Publish date | Apr 27, 2010 (structure data deposition date) |
Authors | Down, K. / Bamborough, P. / Alder, C. / Campbell, A. / Christopher, J.A. / Gerelle, M. / Ludbrook, S. / Mallett, D. / Mellor, G. / Miller, D.D. ...Down, K. / Bamborough, P. / Alder, C. / Campbell, A. / Christopher, J.A. / Gerelle, M. / Ludbrook, S. / Mallett, D. / Mellor, G. / Miller, D.D. / Pearson, R. / Ray, K. / Solanke, Y. / Somers, D. |
External links | Bioorg. Med. Chem. Lett. / PubMed:20570148 |
Methods | X-ray diffraction |
Resolution | 1.89 Å |
Structure data | PDB-3mpt: |
Chemicals | ChemComp-1GK: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / P38 / SERINE/THREONINE PROTEIN KINASE / MAP KINASE / Pyrrole-2-Carboxamides / inhibitor / TRANSFERASE-TRANSFERASE INHIBIATOR complex / TRANSFERASE-TRANSFERASE INHIBITOR complex |