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Structure paper

TitleThe discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38alpha MAP kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 3936-3940, Year 2010
Publish dateApr 27, 2010 (structure data deposition date)
AuthorsDown, K. / Bamborough, P. / Alder, C. / Campbell, A. / Christopher, J.A. / Gerelle, M. / Ludbrook, S. / Mallett, D. / Mellor, G. / Miller, D.D. ...Down, K. / Bamborough, P. / Alder, C. / Campbell, A. / Christopher, J.A. / Gerelle, M. / Ludbrook, S. / Mallett, D. / Mellor, G. / Miller, D.D. / Pearson, R. / Ray, K. / Solanke, Y. / Somers, D.
External linksBioorg. Med. Chem. Lett. / PubMed:20570148
MethodsX-ray diffraction
Resolution1.89 Å
Structure data

PDB-3mpt:
Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

Chemicals

ChemComp-1GK:
N-(furan-2-ylmethyl)-4-[(2-methylphenyl)carbonyl]-1H-pyrrole-2-carboxamide

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / P38 / SERINE/THREONINE PROTEIN KINASE / MAP KINASE / Pyrrole-2-Carboxamides / inhibitor / TRANSFERASE-TRANSFERASE INHIBIATOR complex / TRANSFERASE-TRANSFERASE INHIBITOR complex

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