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TitleDesign and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 4045-, Year 2010
Publish dateMay 19, 2010 (structure data deposition date)
AuthorsMatthews, T.P. / Mchardy, T. / Klair, S. / Boxall, K. / Fisher, M. / Cherry, M. / Allen, C.E. / Addison, G.J. / Ellard, J. / Aherne, G.W. ...Matthews, T.P. / Mchardy, T. / Klair, S. / Boxall, K. / Fisher, M. / Cherry, M. / Allen, C.E. / Addison, G.J. / Ellard, J. / Aherne, G.W. / Westwood, I.M. / Montfort, R.V. / Garrett, M.D. / Reader, J.C. / Collins, I.
External linksBioorg. Med. Chem. Lett. / PubMed:20561787
MethodsX-ray diffraction
Resolution2.25 - 2.7 Å
Structure data

PDB-2xey:
Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-2xez:
Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-2xf0:
Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-YVQ:
3-(1H-INDOL-3-YL)-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE

ChemComp-HOH:
WATER

ChemComp-XEZ:
6-(1H-PYRAZOL-3-YL)-3-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-4UB:
3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / DNA REPAIR / CELL CYCLE

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