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TitleA human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.
Journal, issue, pagesMol. Cancer Ther., Vol. 9, Page 1809-1819, Year 2010
Publish dateNov 17, 2009 (structure data deposition date)
AuthorsDransfield, D.T. / Cohen, E.H. / Chang, Q. / Sparrow, L.G. / Bentley, J.D. / Dolezal, O. / Xiao, X. / Peat, T.S. / Newman, J. / Pilling, P.A. ...Dransfield, D.T. / Cohen, E.H. / Chang, Q. / Sparrow, L.G. / Bentley, J.D. / Dolezal, O. / Xiao, X. / Peat, T.S. / Newman, J. / Pilling, P.A. / Phan, T. / Priebe, I. / Brierley, G.V. / Kastrapeli, N. / Kopacz, K. / Martik, D. / Wassaf, D. / Rank, D. / Conley, G. / Huang, Y. / Adams, T.E. / Cosgrove, L.
External linksMol. Cancer Ther. / PubMed:20515953
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-3kr3:
Crystal structure of IGF-II antibody complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody-target complex / Carbohydrate metabolism / Glucose metabolism / Glycoprotein / Growth factor / Hormone / Mitogen / Osteogenesis / Secreted

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