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Structure paper

TitleStructural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Journal, issue, pagesNature, Vol. 465, Page 818-822, Year 2010
Publish dateFeb 17, 2010 (structure data deposition date)
AuthorsFrank, F. / Sonenberg, N. / Nagar, B.
External linksNature / PubMed:20505670
MethodsX-ray diffraction
Resolution1.691 - 2.095 Å
Structure data

PDB-3luc:
Crystal structure of MID domain from hAGO2
Method: X-RAY DIFFRACTION / Resolution: 1.691 Å

PDB-3lud:
Crystal structure of MID domain from hAGO2 in complex with AMP
Method: X-RAY DIFFRACTION / Resolution: 2.095 Å

PDB-3lug:
Crystal structure of MID domain from hAGO2 in complex with CMP
Method: X-RAY DIFFRACTION / Resolution: 1.849 Å

PDB-3luh:
Crystal structure of MID domain from hAGO2 in complex with GMP
Method: X-RAY DIFFRACTION / Resolution: 1.999 Å

PDB-3luj:
Crystal structure of MID domain from hAGO2 in complex with UMP
Method: X-RAY DIFFRACTION / Resolution: 1.796 Å

PDB-3luk:
Crystal structure of MID domain from hAGO2
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-C5P:
CYTIDINE-5'-MONOPHOSPHATE

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-U5P:
URIDINE-5'-MONOPHOSPHATE

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / MID domain / Ribonucleoprotein / RNA-binding / RNA-mediated gene silencing / Translation regulation

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