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Structure paper

TitleHedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 26570-26580, Year 2010
Publish dateMay 7, 2010 (structure data deposition date)
AuthorsMaun, H.R. / Wen, X. / Lingel, A. / de Sauvage, F.J. / Lazarus, R.A. / Scales, S.J. / Hymowitz, S.G.
External linksJ. Biol. Chem. / PubMed:20504762
MethodsX-ray diffraction
Resolution1.83 - 1.9 Å
Structure data

PDB-3mxv:
Crystal structure of fab fragment of anti-Shh 5E1 chimera
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3mxw:
Crystal structure Sonic hedgehog bound to the 5E1 fab fragment
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / chimera / fab fragment / antibody / sonic hedgehog / SIGNALING PROTEIN / antibody complex / metalloprotease / calcium binding / zinc hydrolase / development / morphogen

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