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TitleStructural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
Journal, issue, pagesJ. Mol. Biol., Vol. 400, Page 413-433, Year 2010
Publish dateFeb 25, 2010 (structure data deposition date)
AuthorsChrencik, J.E. / Patny, A. / Leung, I.K. / Korniski, B. / Emmons, T.L. / Hall, T. / Weinberg, R.A. / Gormley, J.A. / Williams, J.M. / Day, J.E. ...Chrencik, J.E. / Patny, A. / Leung, I.K. / Korniski, B. / Emmons, T.L. / Hall, T. / Weinberg, R.A. / Gormley, J.A. / Williams, J.M. / Day, J.E. / Hirsch, J.L. / Kiefer, J.R. / Leone, J.W. / Fischer, H.D. / Sommers, C.D. / Huang, H.C. / Jacobsen, E.J. / Tenbrink, R.E. / Tomasselli, A.G. / Benson, T.E.
External linksJ. Mol. Biol. / PubMed:20478313
MethodsX-ray diffraction
Resolution1.65 - 2.5 Å
Structure data

PDB-3lxk:
Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3lxl:
Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-3lxn:
Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3lxp:
Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-MI1:
3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile / medication, inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-IZA:
2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / TYK2 / JAK3 / inflammation / cancer / PAN Inhibitor / ATP-binding / Disease mutation / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / SCID / SH2 domain / Tyrosine-protein kinase

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