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TitleMammal-restricted elements predispose human RET to folding impairment by HSCR mutations.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 17, Page 726-731, Year 2010
Publish dateJan 15, 2010 (structure data deposition date)
AuthorsKjaer, S. / Hanrahan, S. / Totty, N. / McDonald, N.Q.
External linksNat. Struct. Mol. Biol. / PubMed:20473317
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2x2u:
First two Cadherin-like domains from Human RET
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-UNX:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-BU1:
1,4-BUTANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / HIRSCHSPRUNG DISEASE / EXTRACELLULAR DOMAIN / DISEASE MUTATION / GLYCOPROTEIN / TRANSMEMBRANE / KINASE

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