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Title | Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 6, Page 442-448, Year 2010 |
Publish date | Feb 5, 2010 (structure data deposition date) |
Authors | Christ, F. / Voet, A. / Marchand, A. / Nicolet, S. / Desimmie, B.A. / Marchand, D. / Bardiot, D. / Van der Veken, N.J. / Van Remoortel, B. / Strelkov, S.V. ...Christ, F. / Voet, A. / Marchand, A. / Nicolet, S. / Desimmie, B.A. / Marchand, D. / Bardiot, D. / Van der Veken, N.J. / Van Remoortel, B. / Strelkov, S.V. / De Maeyer, M. / Chaltin, P. / Debyser, Z. |
External links | Nat. Chem. Biol. / PubMed:20473303 |
Methods | X-ray diffraction |
Resolution | 1.95 - 2 Å |
Structure data | PDB-3lpt: PDB-3lpu: |
Chemicals | ChemComp-723: ChemComp-PEG: ChemComp-P03: ChemComp-SO4: ChemComp-CA: ChemComp-CL: ChemComp-HOH: ChemComp-976: |
Source |
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Keywords | VIRAL PROTEIN / HIV / integrase / LEDGF/p75 / small molecule / inhibitor / Endonuclease / Hydrolase / Nuclease / Transferase / LEDGF/p75 small molecule |