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Structure paper

TitleStructural Basis of Tbx5-DNA Recognition: The T-Box Domain in its DNA-Bound and -Unbound Form.
Journal, issue, pagesJ. Mol. Biol., Vol. 400, Page 71-, Year 2010
Publish dateFeb 22, 2010 (structure data deposition date)
AuthorsStirnimann, C.U. / Ptchelkine, D. / Grimm, C. / Muller, C.W.
External linksJ. Mol. Biol. / PubMed:20450920
MethodsX-ray diffraction
Resolution1.9 - 2.2 Å
Structure data

PDB-2x6u:
Crystal structure of human TBX5 in the DNA-free form
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-2x6v:
Crystal structure of human TBX5 in the DNA-bound and DNA-free form
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-PE4:
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL / precipitant*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / DEVELOPMENTAL PROTEIN / DNA-BINDING / HOLT-ORAM-SYNDROME / IG-FOLD / NUCLEAR PROTEIN / REPRESSOR / TBX3 / TRANSCRIPTION REGULATION / TRANSCRIPTION/DNA / TRANSCRIPTION-DNA COMPLEX

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