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TitleDiscovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
Journal, issue, pagesJ. Med. Chem., Vol. 53, Page 4399-4411, Year 2010
Publish dateFeb 25, 2010 (structure data deposition date)
AuthorsHofgen, N. / Stange, H. / Schindler, R. / Lankau, H.J. / Grunwald, C. / Langen, B. / Egerland, U. / Tremmel, P. / Pangalos, M.N. / Marquis, K.L. ...Hofgen, N. / Stange, H. / Schindler, R. / Lankau, H.J. / Grunwald, C. / Langen, B. / Egerland, U. / Tremmel, P. / Pangalos, M.N. / Marquis, K.L. / Hage, T. / Harrison, B.L. / Malamas, M.S. / Brandon, N.J. / Kronbach, T.
External linksJ. Med. Chem. / PubMed:20450197
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3lxg:
Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-Z73:
2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsHYDROLASE / PHOSPHODIESTERASE 10A; CATALYTIC DOMAIN / Allosteric enzyme / cAMP / cAMP-binding / cGMP / cGMP-binding / Metal-binding / Nucleotide-binding

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