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Structure paper

TitleActivated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 21070-21081, Year 2010
Publish dateDec 7, 2009 (structure data deposition date)
AuthorsChen, Z. / Medina, F. / Liu, M.Y. / Thomas, C. / Sprang, S.R. / Sternweis, P.C.
External linksJ. Biol. Chem. / PubMed:20430886
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3kz1:
Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / regulation of RhoA GTPase / RhoGEF / DH / PH / Rho / GTPase activation / Guanine-nucleotide releasing factor / Membrane / Cytoskeleton / GTP-binding / Magnesium / Nucleotide-binding / Prenylation / Proto-oncogene

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