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| Title | Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 53, Page 3532-3551, Year 2010 |
| Publish date | Oct 20, 2009 (structure data deposition date) |
 Authors | Beria, I. / Ballinari, D. / Bertrand, J.A. / Borghi, D. / Bossi, R.T. / Brasca, M.G. / Cappella, P. / Caruso, M. / Ceccarelli, W. / Ciavolella, A. ...Beria, I. / Ballinari, D. / Bertrand, J.A. / Borghi, D. / Bossi, R.T. / Brasca, M.G. / Cappella, P. / Caruso, M. / Ceccarelli, W. / Ciavolella, A. / Cristiani, C. / Croci, V. / De Ponti, A. / Fachin, G. / Ferguson, R.D. / Lansen, J. / Moll, J.K. / Pesenti, E. / Posteri, H. / Perego, R. / Rocchetti, M. / Storici, P. / Volpi, D. / Valsasina, B. |
 External links | J. Med. Chem. / PubMed:20397705 |
| Methods | X-ray diffraction |
| Resolution | 2.5 Å |
| Structure data |  PDB-3kb7: |
| Chemicals |  ChemComp-071:  ChemComp-ZN:  ChemComp-TLA:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE / PROTEIN KINASE / ATP-binding / Cell cycle / Cell division / Kinase / Mitosis / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase |
homo sapiens (human)