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-Structure paper
タイトル | Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 20, Page 2998-3002, Year 2010 |
掲載日 | 2010年1月4日 (構造データの登録日) |
![]() | Williams, D.K. / Chen, X.T. / Tarby, C. / Kaltenbach, R. / Cai, Z.W. / Tokarski, J.S. / An, Y. / Sack, J.S. / Wautlet, B. / Gullo-Brown, J. ...Williams, D.K. / Chen, X.T. / Tarby, C. / Kaltenbach, R. / Cai, Z.W. / Tokarski, J.S. / An, Y. / Sack, J.S. / Wautlet, B. / Gullo-Brown, J. / Henley, B.J. / Jeyaseelan, R. / Kellar, K. / Manne, V. / Trainor, G.L. / Lombardo, L.J. / Fargnoli, J. / Borzilleri, R.M. |
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手法 | X線回折 |
解像度 | 2.4 Å |
構造データ | ![]() PDB-3l8v: |
化合物 | ![]() ChemComp-L8V: ![]() ChemComp-HOH: |
由来 |
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![]() | TRANSFERASE / RECEPTOR TYROSINE KINASE / SIGNAL TRANSDUCTION / GRB2 / SHC / ATP-BINDING / GLYCOPROTEIN / MEMBRANE / NUCLEOTIDE-BINDING / PHOSPHOPROTEIN / PROTO-ONCOGENE / TRANSMEMBRANE / TYROSINE-PROTEIN KINASE / Alternative splicing / Chromosomal rearrangement / Disease mutation / Kinase / Polymorphism / Receptor |