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Structure paper

TitleStructure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 17, Page 608-613, Year 2010
Publish dateJan 30, 2010 (structure data deposition date)
AuthorsDiskin, R. / Marcovecchio, P.M. / Bjorkman, P.J.
External linksNat. Struct. Mol. Biol. / PubMed:20357769
MethodsX-ray diffraction
Resolution2.2 - 3.4 Å
Structure data

PDB-3lmj:
Structure of human anti HIV 21c Fab
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3lqa:
Crystal structure of clade C gp120 in complex with sCD4 and 21c Fab
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • hiv-1 (virus)
KeywordsIMMUNE SYSTEM / Immunoglobulin / complex / poly reactivity

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