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-Structure paper
Title | Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 3517-3531, Year 2010 |
Publish date | Nov 6, 2009 (structure data deposition date) |
![]() | Fujimoto, T. / Imaeda, Y. / Konishi, N. / Hiroe, K. / Kawamura, M. / Textor, G.P. / Aertgeerts, K. / Kubo, K. |
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Methods | X-ray diffraction |
Resolution | 1.45 Å |
Structure data | ![]() PDB-3kl6: |
Chemicals | ![]() ChemComp-443: ![]() ChemComp-EDO: ![]() ChemComp-CA: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / coagulation factor Xa / Blood coagulation / Cleavage on pair of basic residues / Disulfide bond / EGF-like domain / Gamma-carboxyglutamic acid / Glycoprotein / Hydroxylation / Protease / Secreted / Serine protease / Zymogen |