タイトル | Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. |
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ジャーナル・号・ページ | Biochemistry, Vol. 49, Page 3766-3773, Year 2010 |
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掲載日 | 2009年8月19日 (構造データの登録日) |
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著者 | Tremblay, L.W. / Fan, F. / Blanchard, J.S. |
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リンク | Biochemistry / PubMed:20353175 |
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手法 | X線回折 |
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解像度 | 1.3 - 2.2 Å |
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構造データ | PDB-3iqa: Crystal Structure of BlaC covalently bound with Doripenem 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3m6b: Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-3m6h: Crystal Structure of Post-isomerized Ertapenem Covalent Adduct with TB B-lactamase 手法: X-RAY DIFFRACTION / 解像度: 1.994 Å |
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化合物 | ChemComp-DRW: (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid
ChemComp-1RG: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid / 薬剤, 抗生剤*YM
ChemComp-2RG: (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid / 薬剤, 抗生剤*YM
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由来 | - mycobacterium tuberculosis (結核菌)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / penicillin binding protein / beta-lactam covalent adduct / Antibiotic resistance / Cell membrane / Hydrolase / Lipoprotein / Membrane / Palmitate / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / Hydrolase/Antibiotic / alpha-beta structure / Hydrolase-Antibiotic complex |
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