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TitleDiscovery of tertiary sulfonamides as potent liver X receptor antagonists.
Journal, issue, pagesJ. Med. Chem., Vol. 53, Page 3412-3416, Year 2010
Publish dateDec 9, 2009 (structure data deposition date)
AuthorsZuercher, W.J. / Buckholz, R.G. / Campobasso, N. / Collins, J.L. / Galardi, C.M. / Gampe, R.T. / Hyatt, S.M. / Merrihew, S.L. / Moore, J.T. / Oplinger, J.A. ...Zuercher, W.J. / Buckholz, R.G. / Campobasso, N. / Collins, J.L. / Galardi, C.M. / Gampe, R.T. / Hyatt, S.M. / Merrihew, S.L. / Moore, J.T. / Oplinger, J.A. / Reid, P.R. / Spearing, P.K. / Stanley, T.B. / Stewart, E.L. / Willson, T.M.
External linksJ. Med. Chem. / PubMed:20345102
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3l0e:
X-ray crystal structure of a Potent Liver X Receptor Modulator
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-G58:
N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / hLXR-beta / human Liver X Receptor-beta / sulfonamide modulator / DNA-binding / Metal-binding / Nucleus / Receptor / Transcription regulation / Zinc-finger / Activator / Phosphoprotein

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