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TitleCrystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 15393-15398, Year 2010
Publish dateFeb 17, 2010 (structure data deposition date)
AuthorsGandhi, P.S. / Chen, Z. / Di Cera, E.
External linksJ. Biol. Chem. / PubMed:20236938
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3lu9:
Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-NA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Serine protease / Acute phase / Blood coagulation / Calcium / Cleavage on pair of basic residues / Disease mutation / Disulfide bond / Gamma-carboxyglutamic acid / Glycoprotein / Kringle / Pharmaceutical / Polymorphism / Protease / Secreted / Zymogen / Cell membrane / G-protein coupled receptor / Membrane / Phosphoprotein / Receptor / Transducer / Transmembrane

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