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TitleInsights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 15874-15883, Year 2010
Publish dateJul 9, 2009 (structure data deposition date)
AuthorsBrandao, T.A. / Hengge, A.C. / Johnson, S.J.
External linksJ. Biol. Chem. / PubMed:20236928
MethodsX-ray diffraction
Resolution2.25 - 2.3 Å
Structure data

PDB-3i7z:
Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-3i80:
Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-VO4:
VANADATE ION

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / P-loop / WPD-loop / Protein Phosphatase / EGFR receptor / Vanadate / Acetylation / Endoplasmic reticulum / Membrane / Oxidation / Phosphoprotein / Polymorphism

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