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TitleDiscovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 2609-2613, Year 2010
Publish dateFeb 5, 2010 (structure data deposition date)
AuthorsPissot-Soldermann, C. / Gerspacher, M. / Furet, P. / Gaul, C. / Holzer, P. / McCarthy, C. / Radimerski, T. / Regnier, C.H. / Baffert, F. / Drueckes, P. ...Pissot-Soldermann, C. / Gerspacher, M. / Furet, P. / Gaul, C. / Holzer, P. / McCarthy, C. / Radimerski, T. / Regnier, C.H. / Baffert, F. / Drueckes, P. / Tavares, G.A. / Vangrevelinghe, E. / Blasco, F. / Ottaviani, G. / Ossola, F. / Scesa, J. / Reetz, J.
External linksBioorg. Med. Chem. Lett. / PubMed:20231096
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3lpb:
Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NVB:
N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Small molecule inhibitor / ATP site kinase inhibitor / Novartis product NVP-BLU040 / ATP-binding / Chromosomal rearrangement / Disease mutation / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Proto-oncogene / SH2 domain / Tyrosine-protein kinase

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