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TitleCrystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.
Journal, issue, pagesFebs Lett., Vol. 584, Page 1455-1462, Year 2010
Publish dateDec 17, 2009 (structure data deposition date)
AuthorsWielens, J. / Headey, S.J. / Jeevarajah, D. / Rhodes, D.I. / Deadman, J. / Chalmers, D.K. / Scanlon, M.J. / Parker, M.W.
External linksFebs Lett. / PubMed:20227411
MethodsX-ray diffraction
Resolution1.4 - 2 Å
Structure data

PDB-3l3u:
Crystal structure of the HIV-1 integrase core domain to 1.4A
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-3l3v:
Structure of HIV-1 integrase core domain in complex with sucrose
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CD:
Unknown entry

Source
  • human immunodeficiency virus 1
KeywordsVIRAL PROTEIN / DNA INTEGRATION / AIDS / INTEGRASE / ENDONUCLEASE / POLYNUCLEOTIDYL TRANSFERASE / DNA BINDING

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