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TitleSystematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
Journal, issue, pagesJ. Mol. Biol., Vol. 398, Page 200-213, Year 2010
Publish dateFeb 3, 2010 (structure data deposition date)
AuthorsLi, C. / Pazgier, M. / Yuan, W. / Liu, M. / Wei, G. / Lu, W.Y. / Lu, W.
External linksJ. Mol. Biol. / PubMed:20226197
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-3lnz:
Crystal structure of human MDM2 with a 12-mer peptide inhibitor PMI (N8A mutant)
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

KeywordsLIGASE/LIGASE INHIBITOR / P53-BINDING PROTEIN of MDM2 / ONCOPROTEIN MDM2 / HUMAN DOUBLE MINUTE 2 PROTEIN / HDM2 / MDM2-peptide inhibitor complex / p53 peptide activator N8A-PMI / Host-virus interaction / Ligase / Metal-binding / Nucleus / Phosphoprotein / Proto-oncogene / Ubl conjugation pathway / Zinc-finger / LIGASE-LIGASE INHIBITOR complex

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