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Structure paper

TitleStructural basis for feedback and pharmacological inhibition of Saccharomyces cerevisiae glutamate cysteine ligase.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 14459-14466, Year 2010
Publish dateFeb 22, 2010 (structure data deposition date)
AuthorsBiterova, E.I. / Barycki, J.J.
External linksJ. Biol. Chem. / PubMed:20220146
MethodsX-ray diffraction
Resolution2.2 - 2.5 Å
Structure data

PDB-3lvv:
BSO-inhibited ScGCL
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3lvw:
Glutathione-inhibited ScGCL
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-LBP:
(2S)-2-amino-4-(S-butyl-N-phosphonosulfonimidoyl)butanoic acid

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

ChemComp-GSH:
GLUTATHIONE

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsLIGASE / glutathione / atp-grasp / atp-binding / glutathione biosynthesis / nucleotide-binding / Phosphoprotein

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