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TitleDiscovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.
Journal, issue, pagesJ. Med. Chem., Vol. 53, Page 2973-2985, Year 2010
Publish dateJan 22, 2010 (structure data deposition date)
AuthorsPettus, L.H. / Wurz, R.P. / Xu, S. / Herberich, B. / Henkle, B. / Liu, Q. / McBride, H.J. / Mu, S. / Plant, M.H. / Saris, C.J. ...Pettus, L.H. / Wurz, R.P. / Xu, S. / Herberich, B. / Henkle, B. / Liu, Q. / McBride, H.J. / Mu, S. / Plant, M.H. / Saris, C.J. / Sherman, L. / Wong, L.M. / Chmait, S. / Lee, M.R. / Mohr, C. / Hsieh, F. / Tasker, A.S.
External linksJ. Med. Chem. / PubMed:20218619
MethodsX-ray diffraction
Resolution3.31 Å
Structure data

PDB-3lhj:
Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor.
Method: X-RAY DIFFRACTION / Resolution: 3.31 Å

Chemicals

ChemComp-LHJ:
N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Serine/Threonine-Protein Kinase / Alternative splicing / ATP-binding / Cytoplasm / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism

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