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Structure paper

TitleStructural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma.
Journal, issue, pagesMol. Endocrinol., Vol. 24, Page 923-929, Year 2010
Publish dateDec 7, 2009 (structure data deposition date)
AuthorsJin, L. / Martynowski, D. / Zheng, S. / Wada, T. / Xie, W. / Li, Y.
External linksMol. Endocrinol. / PubMed:20203100
MethodsX-ray diffraction
Resolution1.74 - 2.4 Å
Structure data

PDB-3kyt:
Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-3l0j:
Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3l0l:
Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-HC2:
20-HYDROXYCHOLESTEROL

ChemComp-HOH:
WATER

ChemComp-HC9:
(3alpha,8alpha,22R)-cholest-5-ene-3,22-diol

ChemComp-HC3:
25-HYDROXYCHOLESTEROL / antivirus*YM

Source
  • homo sapiens (human)
KeywordsLIPID BINDING PROTEIN / ROR / nuclear receptors / Alternative splicing / DNA-binding / Metal-binding / Nucleus / Receptor / Transcription / Transcription regulation / Zinc / Zinc-finger / Acetylation / Activator / Phosphoprotein / Polymorphism / ROR gamma / nuclear receptor / RORgamma

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